解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::In contrast to long bone osteosarcoma, mandibular osteosarcoma is highly heterogeneous and morphologically overlaps with benign tumors, obscuring diagnosis and treatment selection. Molecular characterization is difficult due to the paucity of available specimens of this rare disease. We aimed to characterize the spect...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.11.012
更新日期:2016-04-01 00:00:00
abstract::Endothelial cell injury may contribute to the progression of various glomerular diseases. In the present study, we examined glomerular capillary injury in acute and chronic glomerular lesions in patients with Immunoglobulin A nephropathy (IgAN). We selected renal biopsy samples of IgAN (n = 200), and glomerular capill...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.10.013
更新日期:2016-03-01 00:00:00
abstract::Although the histologic appearance of pure testicular teratomas (PTTs) is similar in children and adults, the prognosis is dramatically different. Prepubertal PTTs are rare, with a benign clinical course, whereas the adult cases typically have malignant outcomes. Chromosome 12p abnormalities are seen in most adult tes...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2015.10.003
更新日期:2016-03-01 00:00:00
abstract::We report here an exceptional pattern of atypical lentiginous melanocytic proliferation within an adenoma, leading to focal lamina propria infiltration and pulmonary metastasis, which was considered as primary colonic mucosal melanoma (MM) in a Caucasian patient. Such case illustrates the diagnosis criteria required t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.09.025
更新日期:2016-02-01 00:00:00
abstract::Heterotopic pancreatic parenchyma recapitulates the normal pancreas in extrapancreatic locations and, on rare occasions, can even give rise to pancreatic adenocarcinoma. The genetic signatures of pancreatic adenocarcinoma and its precursor lesions are well characterized. We explored the genetic alterations in precurso...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.09.023
更新日期:2016-02-01 00:00:00
abstract::Aquaporin 5 (AQP5) is an androgen-regulated member of a family of small hydrophobic integral transmembrane water channel proteins regulating cellular water homeostasis and growth signaling. To evaluate its clinical impact and relationship with key genomic alterations in prostate cancer, AQP5 expression was analyzed by...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.09.026
更新日期:2016-02-01 00:00:00
abstract::The objective of this study was to analyze the expression and clinical role of the RNA-binding molecule HuR in metastatic high-grade ovarian serous carcinoma (HGSC). HUR mRNA expression by reverse-transcription polymerase chain reaction was analyzed in 66 effusions from patients diagnosed with HGSC. Protein expression...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.09.027
更新日期:2016-02-01 00:00:00
abstract::Complete age-related regression of mammary epithelium, often termed postmenopausal involution, is associated with decreased breast cancer risk. However, most studies have qualitatively assessed involution. We quantitatively analyzed epithelium, stroma, and adipose tissue from histologically normal breast tissue of 454...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.09.031
更新日期:2016-02-01 00:00:00
abstract::Fibroepithelial lesions (FEL) of the breast are notoriously difficult to classify on core needle biopsies. The goal of this study was to evaluate interobserver variability and accuracy of subclassifying difficult FELs into fibroadenoma (FA) and phyllodes tumors (PTs). We identified 50 breast core needle biopsies, init...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.09.001
更新日期:2016-01-01 00:00:00
abstract::PELP1 is a novel coregulator of nuclear hormone receptors and is implicated in playing a role in driving breast cancer and enhancing metastatic potential. The PELP1 protein expression and potential role of PELP1 in triple-negative breast carcinoma (TNBC) have not been well characterized. We investigated PELP1 expressi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.07.023
更新日期:2015-12-01 00:00:00
abstract::Chemokine receptor, CXCR3, has been increasingly reported to be involved in tumorigenesis and tumor progression, but limited data are available regarding the expression of CXCR3 in gastric cancer (GC). In the present study, the expressions of CXCR3 and its variants were detected in 96 GC and corresponding nontumor gas...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.08.004
更新日期:2015-12-01 00:00:00
abstract::Extramammary Paget disease (EMPD) has been known to frequently express androgen receptor (AR). Therefore, androgens could play roles in the biological behavior of Paget cells. 5α-Reductase (5α-red) types 1 and 2 and 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5) are pivotal in situ regulators of androgen productio...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.07.007
更新日期:2015-11-01 00:00:00
abstract::Histologic prognostic parameters in papillary renal cell carcinoma (PRCC) are unclear. The aims were to review the clinicopathological features of PRCC, including Fuhrman grade and International Society of Urological Pathology (ISUP) nucleolar grade, and to identify parameters that may be independent prognostic indica...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.07.001
更新日期:2015-10-01 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) plays a pivotal role in tumor invasion and metastasis in various malignancies. ZEB2/SIP1 is an important EMT regulator and down-regulates E-cadherin expression. The present study was planned to explore status of EMT-associated markers ZEB2/SIP1 and E-cadherin in eyelid sebaceous...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.05.026
更新日期:2015-10-01 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is the most common oral cancer, and major efforts is being made to identify molecular markers capable to differentiate oral potentially malignant lesions (OPMLs) with indolent course from lesions with aggressive behavior. We undertook a study to evaluate if gain of the human telomer...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.05.013
更新日期:2015-09-01 00:00:00
abstract::Ovarian cancer, consisting predominantly of ovarian carcinoma, is the eighth most common cancer in women and the most lethal gynecologic malignancy. Efforts focus on identifying biomarkers which may aid in early diagnosis and reduce mortality, as well as on characterizing therapeutic targets with the aim of circumvent...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2015.06.013
更新日期:2015-09-01 00:00:00
abstract::Merkel cell polyomavirus is of oncogenic significance in approximately 80% of Merkel cell carcinomas. Morphological subcategories of the tumor differ in regard to viral status, the rare combined type being uniformly virus negative and the predominant pure type being mainly virus positive. Indications that different bi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.05.008
更新日期:2015-09-01 00:00:00
abstract::Lymphoplasmacytic infiltrates in the breast, a modified skin appendage, include lymphocytic lobulitis, other nonspecific benign proliferations, and mucosa-associated lymphoid tissue (MALT)-type lymphoma. Distinguishing these entities, all of which may be B-cell rich and may have associated sclerosis, can be difficult....
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.04.006
更新日期:2015-08-01 00:00:00
abstract::Basal cell carcinoma (also referred to as adenoid cystic carcinoma) is a rare tumor of the prostate. Although largely characterized as indolent, poor outcomes have been reported in a considerable fraction of cases. As yet, optimum treatment strategies for this cancer have not been developed. This study investigates pr...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.02.004
更新日期:2015-06-01 00:00:00
abstract::Automatic quantification of cardinal histologic features of nonalcoholic fatty liver disease (NAFLD) may reduce human variability and allow continuous rather than semiquantitative assessment of injury. We recently developed an automated classifier that can detect and quantify macrosteatosis with greater than or equal ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.01.019
更新日期:2015-05-01 00:00:00
abstract::The objective of this cohort study was to evaluate whether the immunohistochemical expression of tissue inhibitor of metalloprotease 2, matrix metalloproteinase (MMP) 2, and MMP-9 could predict the occurrence of death and progression in women with ovarian high-grade serous carcinoma (HGSC). A total of 100 women with p...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.01.014
更新日期:2015-05-01 00:00:00
abstract::Oral cancer overexpressed 1 (ORAOV1) has been reported to exhibit high amplification levels in esophageal squamous cell cancer (ESCC) and in premalignant lesions. However, ORAOV1 protein expression levels in ESCC and esophageal squamous intraepithelial neoplasia (ESIN) have not yet been reported. We have explored the ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.01.009
更新日期:2015-05-01 00:00:00
abstract::We report 2 ovarian neoplasms in women aged 58 and 69 years composed of an admixture of adenosarcoma and a predominant stromal component morphologically and immunohistochemically in keeping with juvenile granulosa cell tumor. As far as we are aware, this association has not been reported previously. We speculate that,...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.12.010
更新日期:2015-04-01 00:00:00
abstract::Pediatric follicular lymphoma (pFL) is a rare neoplasm with features differing from follicular lymphoma arising in adults. Here, we describe a rare case of pFL that showed morphologic features partially overlapping with progressive transformation of germinal centers and reactive follicular hyperplasia. As typical of p...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.12.016
更新日期:2015-04-01 00:00:00
abstract::Basal cells of benign prostate glands are typically p63 positive, whereas malignant glands are usually p63 negative. A rare subset of prostatic adenocarcinoma (PCa) demonstrates aberrant diffuse p63 expression but is negative for high-molecular-weight cytokeratin. Strong p63 staining of the tumor cells can obscure the...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.11.011
更新日期:2015-03-01 00:00:00
abstract::Histopathologic diagnosis of adrenocortical tumors is based on adverse features that indicate malignant potential. Proliferation index has served as a supplemental tool in assessing the malignant potential of adrenocortical tumors. None of the current histologic classification systems can sufficiently accurately predi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.11.015
更新日期:2015-03-01 00:00:00
abstract::Clear cell renal cell carcinoma (CCRCC) is the most common renal cell carcinoma. It has a relatively unfavorable prognosis compared to other common renal cell carcinomas. Recently, comprehensive molecular studies in CCRCC revealed important genetic alterations, including changes in the VHL, PBRM1, and ARID1A genes. Th...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.12.002
更新日期:2015-03-01 00:00:00
abstract::Hyalinizing clear cell carcinoma (HCCC) has only been described in salivary glands of the head and neck. We report a 38-year-old man with a 2.6-cm lung tumor that was growing in a peribronchial location and had morphologic features of HCCC. The tumor cells expressed cytokeratin 7 and keratin AE1/AE3, and the vast majo...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.11.010
更新日期:2015-03-01 00:00:00
abstract::Primary mediastinal seminomas are unusual tumors that can present in a pure form or as part of a mixed germ cell tumor. Contrary to testicular seminomas, little is known about the expression of novel immunohistochemical markers in mediastinal seminomas. This study investigates the immunohistochemical features of these...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.11.009
更新日期:2015-03-01 00:00:00
abstract::Extranodal natural killer (NK)/T-cell lymphoma, nasal type, is a predominantly extranodal lymphoma associated with Epstein-Barr virus occurring most frequently in the upper aerodigestive tract. There are limited reports on cellular origin and prognostic factors. We retrospectively investigated 73 cases with a median a...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.11.008
更新日期:2015-02-01 00:00:00
abstract::The pathogenesis of lacaziosis continues to be obscure, and works have investigated the blood systemic immune response or the dermal immune response in restricted lesions in different body regions. Some authors describe that the inflammatory infiltrate in lacaziosis lesions showed a predominance of macrophages followe...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.10.016
更新日期:2015-02-01 00:00:00
abstract::Hydrophilic polymers are commonly applied as surface coatings on vascular devices and have been shown to dissociate during endovascular use, causing hydrophilic polymer embolism (HPE). Adverse effects related to this phenomenon have been recognized and reported. The prevalence of this complication is unknown. We condu...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.09.011
更新日期:2015-02-01 00:00:00
abstract::Carcinoma ex-pleomorphic adenoma (CA ex-PA) is a malignant salivary gland tumor that arises in association with pleomorphic adenoma (PA). Both PA and CA ex-PA have a broad spectrum of histology, and distinction from their histologic mimics may be difficult based on morphology alone. PLAG1 and HMGA2 abnormalities are t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.08.017
更新日期:2015-01-01 00:00:00
abstract::A 39-year-old female patient was admitted to explore chronic renal failure. Clinical history included silicone breast implants. Clinical examination was normal. Urinalysis revealed tubular proteinuria with Bence-Jones κ protein. Monoclonal immunoglobulin G κ and free monoclonal κ-light chains (LCs) were revealed by se...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.10.008
更新日期:2015-01-01 00:00:00
abstract::We describe the pathology of 5 patients with germline PRKACA copy number gain and Cushing syndrome: 4 males and 1 female, aged 2 to 43 years, including a mother and son. Imaging showed normal or slightly enlarged adrenal glands in 4 patients and a unilateral mass in the fifth. Biochemically, the patients had corticotr...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.09.005
更新日期:2015-01-01 00:00:00
abstract::The pathology report is a critical document that helps guide the management of patients with cancer. More and more patients read their reports, intending to participate in decisions about their care. However, a substantial subset of patients may lack the ability to comprehend this often technical and complex document....
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2014.07.008
更新日期:2014-11-01 00:00:00
abstract::To analyze the differentiation characteristics of extranodal natural killer/T-cell lymphoma, nasal type, one nude mouse model, cell lines SNK6 and SNT8, and 16 fresh human samples were analyzed by flow cytometry immunophenotyping and immunohistochemistry staining; and 115 archived cases were used for phenotypic detect...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.04.024
更新日期:2014-11-01 00:00:00
abstract::Insulin-like growth factor II messenger RNA (mRNA)-binding protein 3 (IMP3) is an oncofetal protein that promotes tumor progression and metastasis in a number of malignancies. However, the clinical significance of IMP3 expression in squamous cell carcinoma (SCC) of the uterine cervix is unclear. In this study, the cor...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.07.006
更新日期:2014-11-01 00:00:00
abstract::δ-Like ligand 4 (DLL4), a ligand for the Notch family of receptors, forecasts the prognosis of several human malignancies. However, the expression and role of DLL4 in breast cancer remain largely unknown. In the present study, we first evaluated whether the overexpression of DLL4 could be used as an indicator of axill...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.04.025
更新日期:2014-11-01 00:00:00
abstract::AT-rich interactive domain 1A (ARID1A) is tumor suppressor gene that interacts with BRG1 adenosine triphosphatase to form a SWI/SNF chromatin remodeling protein complex. Inactivation of ARID1A has been described in several neoplasms, including epithelial ovarian and endometrial carcinomas, and has been correlated with...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.07.003
更新日期:2014-11-01 00:00:00